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In addition, pilocarpine causes the pupil to become smaller and reduces its response to light or dark conditions. Pilocarpine ophthalmic preparations should only be given during pregnancy when benefit outweighs risk. The following information includes only the average doses of ophthalmic pilocarpine. To avoid extensive neuroradiological tests, instillation of 1% pilocarpine solution is recommended as an aid in the diagnosis of non-neurogenic dilation of the pupil. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization.

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