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metoclopramide facts from trusted sources:

Although the risk of tardive dyskinesia (TD) with metoclopramide has not been extensively studied, one published study reported a TD prevalence of 20% among patients treated for at least 3 months. The kinetics of metoclopramide in the presence of renal impairment remained linear however. Of the 85% eliminated in the urine, about half is present as free or conjugated metoclopramide. The effect of metoclopramide on motility is not dependent on intact vagal innervation, but it can be abolished by anticholinergic drugs. Current product labeling warns of the risk of tardive dyskinesia with chronic metoclopramide treatment.

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